Volume 2.33 | Sep 3

Immune Regulation News 2.33, September 3, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

When It Comes to the Immune System, We’re All More Alike Than Previously Thought, Study Finds  ShareThis
Researchers developed a novel way to sequence millions of T cell receptors, a critical component of the human adaptive immune system, simultaneously from a single sample. [Press release from the Fred Hutchinson Cancer Research Center discussing online prepublication in Science Translational Medicine]

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SCIENCE NEWS

Study Points to Key Genetic Driver of Severe Asthma
Scientists have identified a genetic basis for determining the severity of allergic asthma in experimental models of the disease. [Press release from the Cincinnati Children’s Hospital Medical Center discussing online prepublication in Nature Immunology]

Bloodstream’s ‘Band-Aids’ Bad for Lupus
The blood-clotting cells called platelets are usually good guys, stanching wounds so that we don’t bleed to death. But for people with lupus, the cells are villains that exacerbate the disease, according to a new study. [Press release from ScienceNow discussing online prepublication in Science Translational Medicine]

LRI-Funded Funded Study Points to Increased Risk for Lupus in Men
Researchers at the University of California Los Angeles have discovered that humans-males in particular-with a variant form of toll-like receptor 7 are at increased risk of developing the autoimmune disease systemic lupus erythematosus. [Press release from the Lupus Research Institute discussing online prepublication in the Proceedings of the National Academy of Sciences U.S.A]

Why Fish Oils Work Swimmingly Against Diabetes
Researchers have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance. [Press release from the University of California, San Diego School of Medicine discussing online prepublication in Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
Here, researchers show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 fatty acid receptor/sensor. [Cell]

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial Gamma-Delta-T Cell Activation
Here, researchers identify an epithelial T cell-specific costimulatory molecule, junctional adhesion molecule-like protein (JAML). [Science]

Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire
Researchers sequenced the complementarity-determining region 3 (CDR3) regions from millions of rearranged T cell receptor beta chain genes in naïve and memory CD8+ T cells of seven adults. [Sci Transl Med]

Platelet CD154 Potentiates Interferon-Alpha Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus
Together, the data identify platelet activation as an important contributor to systemic lupus erythematosus pathogenesis and suggest that this process and its sequelae may provide a new therapeutic target. [Sci Transl Med]

Complement-Mediated Regulation of the IL-17A Axis is a Central Genetic Determinant of the Severity of Experimental Allergic Asthma
Here, researchers demonstrate that IL-17A mediated severe airway hyperresponsiveness in susceptible strains of mice by enhancing IL-13-driven responses. [Nat Immunol]

The Transcription Cofactor Hopx is Required for Regulatory T Cell Function in Dendritic Cell-Mediated Peripheral T Cell Unresponsiveness
Researchers report a critical role for the transcription cofactor homeodomain-only protein (Hop; also known as Hopx) in induced regulatory T cells to mediate T cell unresponsiveness in vivo. [Nat Immunol]

Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity Against Helminths
These results demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation, whereas primary T helper 2 cell responses can operate efficiently in the absence of this cell type. [Immunity]

Th17 Immune Responses Contribute to the Pathophysiology of Aplastic Anemia
Th17 immune responses contribute to aplastic anemia pathophysiology, especially at the early stage during disease progression. [Blood]

Sex-Specific Association of X-Linked Toll-Like Receptor 7 (TLR7) With Male Systemic Lupus Erythematosus
The data established a functional polymorphism in type I IFN pathway gene TLR7 predisposing to systemic lupus erythematosus, especially in Chinese and Japanese male subjects. [Proc Natl Acad Sci USA]

COX-2 Inhibition Improves Immunotherapy and is Associated with Decreased Numbers of Myeloid-Derived Suppressor Cells in Mesothelioma
Here researchers investigate if the in vivo immunoregulatory function of myeloid-derived suppressor cells (MDSC) can be reversed by inhibiting prostaglandin synthesis by specific COX-2 inhibition focusing on reactive oxygen species production by MDSC subtypes. [BMC Cancer]

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INDUSTRY NEWS

Isotechnika Pharma and 3SBio Announce Strategic Partnership to Develop and Commercialize Voclosporin in China
Isotechnika Pharma Inc. and 3SBio Inc. announced the signing of a development and commercialization agreement for voclosporin, a next generation calcineurin inhibitor being developed for use in the prevention of organ rejection following transplantation and the treatment of autoimmune diseases. [Isotechnika Pharma Inc. Press Release]

ImmunoSolv Merges with Grampian BioConsultants & Secures Additional Funds
ImmunoSolv, a leading Edinburgh-based private company developer of immunology platform technology, is pleased to announce that it has completed a merger with Aberdeen-based Grampian BioConsultants Limited. The merged company will retain the name ImmunoSolv Limited. [ImmunoSolv Limited Press Release]


POLICY NEWS

NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]

National Cancer Institute’s Best Practices for Biospecimen Resources (FR Doc. 2010-20872) [National Institutes of Health, United States]

Revolutionary Genome Sequencing Technologies — The $1000 Genome (SBIR [R43/R44]) (RFA-HG-10-014) [National Institutes of Health, United States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [FR Doc. 2010-20834] [Food and Drug Administration, United States]



EVENTS (Listed by Date)

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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