Volume 2.32 | Aug 27

Immune Regulation News 2.32, August 27, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


A Pharmacy On the Back of a Cell  ShareThis
Drugs encapsulated in new MIT nanoparticles can hitch a ride to tumors on the surface of immune-system cells. The new method could also be used to deliver other types of cancer drugs or to promote blood-cell maturation in bone-marrow transplant recipients, according to the researchers. [Press release from the Massachusetts Institute of Technology online prepublication in Nature Medicine]

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Diabetes Can Cause a Sugar Coating that Smothers Body’s Immune Defences
Research has found that unhealthy glucose levels in patients with diabetes can cause significantly more problems for the body than just the well-known symptoms of the disease such as kidney damage and circulation problems. [Press release from the University of Warwick discussing online prepublication in Immunobiology]

Statement on XMRV/Chronic Fatigue Syndrome Positive Replication Study Confirms WPI’s Findings
The Whittemore Peterson Institute(WPI) would like to congratulate the distinguished authors of the recently released replication study linking XMRV with Chronic Fatigue Syndrome, Dr. Shyh Ching Lo of the Food and Drug Administration (FDA) and Dr. Harvey Alter of the National Institutes of Health(NIH). [The Whittemore Peterson Institute Press Release]

Rheumatoid Arthritis Signaling Protein Reverses Alzheimer’s in Mouse Model
A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer’s disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study reports. [Press release from the University of South Florida discussing online prepublication in the Journal of Alzheimer’s Disease]

Important Breakthrough in Research on the Molecular Mechanisms Underlying the Pathogenesis of Asthma
New findings show that the gene-regulating molecule IRF4 plays a key role in the development of T helper 9 lymphocytes, which can play a major part in the development of this chronic, inflammatory illness of the respiratory tract. [Press release from the University Medical Center of Johannes Gutenberg University Mainz discussing online prepublication in Immunity]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Therapeutic Cell Engineering with Surface-Conjugated Synthetic Nanoparticles
Here, researchers describe a strategy to enhance cell therapy via the conjugation of adjuvant drug-loaded nanoparticles to the surfaces of therapeutic cells. [Nat Med]

The Phosphatase PTP-PEST Promotes Secondary T Cell Responses by Dephosphorylating the Protein Tyrosine Kinase Pyk2
To determine the function of PTP-PEST in T cells, researchers generated mice with a conditionally deleted allele of Ptpn12. [Immunity]

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity
Given recent data linking A20 (TNFAIP3 ) with human B cell lymphomas and systemic lupus erythematosus, researchers have generated mice bearing a floxed allele of TNFAIP3 to interrogate A20’s roles in regulating B cell functions. [Immunity]

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
The studies identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity. [Immunity]

Th17 Immune Responses Contribute to the Pathophysiology of Aplastic Anemia
Th17 immune responses contribute to aplastic anemia pathohysiology, especially at the early stage during disease progression. [Blood]

Deep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B Cells Identifies Hundreds of Novel MicroRNAs
Researchers elucidated the complete small RNA transcriptome of normal and malignant B cells through deep sequencing of 31 normal and malignant human B cell samples that comprise the spectrum of B cell differentiation and common malignant phenotypes. [Blood]

IL-25: A Cytokine Linking Eosinophils and Adaptative Immunity in Churg-Strauss Syndrome
The findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of Churg-Strauss syndrome. [Blood]

Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production
In this article, researchers show by conditional gene targeting that T cell-specific loss of HDAC1 led to an increased inflammatory response in an in vivo allergic airway inflammation model. [J Immunol]

High Glucose Disrupts Oligosaccharide Recognition Function Via Competitive Inhibition: A Potential Mechanism for Immune Dysregulation in Diabetes Mellitus
Researchers conclude that high glucose disrupts C-type lectin function, potentially illuminating new perspectives on susceptibility to infectious and inflammatory disease in diabetes. [Immunobiology]


CSL Behring Receives FDA Approval to Extend Shelf Life of Hizentra® from 18 Months to 24 Months
CSL Behring announced that the U.S. Food and Drug Administration has approved a supplemental Biologics License Application to extend the shelf life of Hizentra®, Immune Globulin Subcutaneous (Human), 20% Liquid, from 18 months to 24 months. [CSL Behring Press Release]

Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

Taligen Granted Patent for Lead Product Candidate, TT30, and Other Compounds Targeting the Complement System
Taligen Therapeutics announced that the U.S. Patent and Trademark Office has issued U.S. Patent No. 7,759,304, entitled “Targeting Complement Factor H For Treatment of Diseases”, covering the composition of matter for its lead product candidate, TT30, a novel fusion protein that selectively binds to complement activated cells to locally regulate the complement system, as well as other complement receptor 2-Factor H (CR2-FH) fusion compounds. [Businesswire]


NIH Launches Effort to Define Markers of Human Immune Responses to Infection and Vaccination
A new nationwide research initiative has been launched to define changes in the human immune system, using human and not animal studies, in response to infection or to vaccination. [National Institutes of Health, United States]

Lawrence A. Tabak Named Principal Deputy Director NIH
National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]

GlaxoSmithKline and Human Genome Sciences Announce FDA Priority Review Designation for Benlysta® (Belimumab) as a Potential Treatment for Systemic Lupus Erythematosus
GlaxoSmithKline PLC and Human Genome Sciences, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted a priority review designation to Benlysta® (belimumab) as a potential treatment for systemic lupus erythematosus. [Food and Drug Administration, United States]

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States]

Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-20287) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]

NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States]

Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]

Complete List of Currently Approved NDA and ANDA Application Submissions (PDF – 62KB)   [Food and Drug Administration, United States]

EVENTS (Listed by Date)

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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