Volume 2.26 | Jul 16

Immune Regulation News 2.26, July 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

NIH-Led Scientists Find Antibodies that Prevent Most HIV Strains from Infecting Human Cells  ShareThis
Scientists have discovered two potent human antibodies that can stop more than ninety percent of known global HIV strains from infecting human cells in the laboratory, and have demonstrated how one of these disease-fighting proteins accomplishes this feat. [Press release from the National Institutes of Health discussing online prepublication in Science]

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SCIENCE NEWS

Children’s Gut Bacteria Linked to Type I Diabetes
Researchers have found that the variety of bacteria in a child’s digestive tract is strongly linked to whether that child develops type I diabetes. [Press release from the University of Florida discussing online prepublication in The ISME Journal: Multidisciplinary Journal of Microbial Ecology]

UF Scientists Discover Clues to Inflammatory Disease
Through the lens of two inflammation-related diseases, HIV and rheumatoid arthritis, researchers identified changes in specific proteins linked to the action of macrophages. [University of Florida Press Release]

First Step to New Therapy for Chronic Bowel Disease
Scientists have discovered that A20 protein plays an important protective role in diseases associated with chronic bowel inflammation. [VIB (Flanders Institute for Biotechnology) Press Release]

After 40 Years, NIH-Supported Researchers Identify Possible New Treatment for Severe Vasculitis
Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, a rare but devastating disease of blood vessels. [Press release from the National Institute of Allergy and Infectious Diseases discussing online prepublication in The New England Journal of Medicine]

Researchers Create Tumor-Fighting Immune Cells, Watch in Real Time as They Kill Cancer
Researchers created a large, well-armed battalion of tumor-seeking immune system cells and used positron emission tomography (PET) to watch in real time as these special forces traveled throughout the body to locate and attack dangerous melanomas. [Press release from the Jonsson Comprehensive Cancer Center discussing online prepublication in Proceedings of the National Academy of Sciences United States of America]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
Researchers conducted a multicenter, randomized, double-blind, double-dummy, noninferiority trial of rituximab (375 mg per square meter of body-surface area per week for 4 weeks) as compared with cyclophosphamide (2 mg per kilogram of body weight per day) for remission induction. [N Engl J Med]

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Researchers used knowledge of HIV-1 envelope (Env) structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of CD4 receptor binding. [Science]

T Cells Expressing the Transcription Factor PLZF Regulate the Development of Memory-Like CD8+ T Cells
Several gene-deficiency models promote the development of innate CD8+ T cells that have diverse T cell antigen receptors but have a memory phenotype and rapidly produce cytokines. Researchers demonstrate here that similar cells developed in mice deficient in the transcription factor KLF2. [Nat Immunol]

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways During Respiratory Virus Challenge
Here, researchers demonstrate that although airway-resident memory CD8+ T cells were poorly cytolytic, memory CD8+ T cells recruited to the airways early during a recall response showed markedly enhanced cytolytic ability. [Immunity]

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation
Here researchers showed that repetitive antigen stimulations induced accumulation of memory CD8+ T cells with uniform effector memory characteristics. [Immunity]

K33-Linked Polyubiquitination of T Cell Receptor-Zeta Regulates Proteolysis-Independent T Cell Signaling
Researchers describe that in mice deficient in the E3 ubiquitin ligases Cbl-b and Itch, T cell activation was augmented, accompanied by spontaneous autoimmunity. [Immunity]

Kinetic Phases of Distribution and Tumor Targeting by T Cell Receptor Engineered Lymphocytes Inducing Robust Antitumor Responses
Adoptive cell transfer of splenocytes from fully immunocompetent HLA-A2.1/Kb mice transduced with a chimeric murine/human T cell receptor specific for tyrosinase, together with lymphodepletion conditioning, dendritic cell-based vaccination, and high-dose interleukin-2, had profound antitumor activity against large established MHC- and antigen-matched tumors. [Proc Natl Acad Sci U S A]

Toward Defining the Autoimmune Microbiome for Type I Diabetes
High-throughput, culture-independent approaches identified bacteria that correlate with the development of type I diabetes-associated autoimmunity in young children who are at high genetic risk for this disorder. [ISME J]

CD30 Discriminates Heat Shock Protein 60-Induced FOXP3+CD4+ T Cells with a Regulatory Phenotype
In this study, researchers demonstrate that highly suppressive FOXP3+ regulatory T cells can be induced in vitro by the activation of CD4+CD25- T cells with the self-antigen human 60-kDa heat shock protein. [J Immunol]

Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis
This study demonstrates that the number of endogenous or adoptively transferred B10 cells directly influenced experimental autoimmune encephalomyelitis pathogenesis through their production of IL-10. [J Immunol]


INDUSTRY NEWS

RegeneRx Awarded Australian Patent for New TB4 Applications
RegeneRx Biopharmaceuticals, Inc. announced it has received Notice of Acceptance from the Australian patent office for the use of Thymosin beta 4 (TB4), its analogues, isoforms and other derivatives in the treatment of infections and inflammatory disorders including colitis, ileitis, gastrointestinal ulcers and gingivitis, among others. [RegeneRx Biopharmaceuticals, Inc. Press Release]

UK Biopharmaceutical Company Will be Built Based on Human Monoclonal Antibody Technology from the Sanger Institute
Kymab and The Wellcome Trust investment division announced a 20 million (pounds) Series A equity financing. [Wellcome Trust Sanger Institute Press Release]


POLICY NEWS

Harold Varmus Sworn in as National Cancer Institute’s 14th Director
Nobel Prize winner Harold E. Varmus, M.D., took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States]

Britain Delays Controversial Assessment Scheme for Research
Britain’s new science minister made good a manifesto pledge when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

Spanish Science Spending Lockdown
Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain]

Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting [Centers for Disease Control and Prevention, United States]

Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]

Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]


EVENTS

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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