Volume 2.25 | Jul 9

Immune Regulation News 2.25, July 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Genetic Basis of Alopecia Areata Established for First Time by Columbia Research Team  ShareThis
A team of investigators has uncovered eight genes that underpin alopecia areata, one of the most common causes of hair loss. [Press release from Columbia University Medical Center discussing online prepublication in Nature]

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Caltech Biologists Discover How T Cells Make a Commitment
When does a cell decide its particular identity? In the case of T cells, the answer is when the cells begin expressing Bcl11b. [Press release from California Institute of Technology discussing online prepublication in Science]

Genetic Regulator Opens New Avenues to AIDS, Immune System Research
Researchers have discovered that a genetic regulator, which is critical to many life functions, also plays a key role in the formation of T cells. [Press release from Oregon State University discussing online prepublication in Science]

Researchers Discover Trigger to Early, Effective Antibody Response
Researchers have discovered a trigger that induces B cells to produce effective and long-lived antibodies early in the immune response. [Press release from National Jewish Health discussing online prepublication in The Journal of Experimental Medicine]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity
Researchers have defined the genetic underpinnings of Alopecia Areata (AA), placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. [Nature]

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b
Researchers found that Bcl11b is necessary for T lineage commitment in mice and is specifically required both to repress natural killer cell-associated genes and to down-regulate a battery of stem cell or progenitor cell genes at the pivotal stage of commitment. [Science] [Science]

T Cells Expressing the Transcription Factor PLZF Regulate the Development of Memory-Like CD8+ T Cells
The findings identify a previously unknown mechanism of regulation of CD8+ T cells via the production of IL-4 by PLZF+ T cells. [Nat Immunol]

MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1
MicroRNAs (miRNAs) can influence lineage choice or affect critical developmental checkpoints during hematopoiesis. Researchers examined the role of the p53-induced microRNA miR-34a in hematopoiesis by gain-of-function analysis in murine bone marrow. [Immunity]

Identification of an Immediate Foxp3- Precursor to Foxp3+ Regulatory T Cells in Peripheral Lymphoid Organs of Nonmanipulated Mice
Researchers compared events early during agonist-driven generation of Foxp3+ TCR transgenic T cells to polyclonal CD4+ T cell populations in unmanipulated mice. [J Exp Med]

B Cell Depletion Reduces the Development of Atherosclerosis in Mice
Researchers unexpectedly show that mature B cell depletion using a CD20-specific monoclonal antibody induces a significant reduction of atherosclerosis in various mouse models of the disease. [J Exp Med]

Vitamins C and E for Prevention of Pre-Eclampsia in Women with Type I Diabetes: A Randomised Placebo-Controlled Trial
Researchers aimed to assess whether supplementation with vitamins C and E reduced incidence of pre-eclampsia in women with type I diabetes. [Lancet Oncol]

NLRC5 Limits the Activation of Inflammatory Pathways
In this study, researchers present the identification and characterization of NLRC5, a nod-like receptor protein whose expression is found predominantly in cells of the myeloid and lymphoid lineages. [J Immunol]

Adipose Tissue and Wharton’s Jelly Derived Mesenchymal Stromal Cells Suppress Lymphocyte Responses by Secreting Leukemia Inhibitory Factor
In this study, researchers investigated the capacity of mesenchymal stromal cells derived from adipose tissue and Wharton’s jelly to modulate lymphocyte proliferation as well as their impact on regulatory T cells. [Tissue Eng Part A]


Calithera Biosciences Closes $40 Million in Series A Financing
Calithera Biosciences, a company developing novel oncology therapeutics, today announced the completion of a Series A financing totaling $40 million. [Calithera Biosciences Press Release]

Sanofi-aventis and JDRF Form Partnership to Improve Therapies, Work Toward Cure for Type I Diabetes
Sanofi-aventis and the Juvenile Diabetes Research Foundation (JDRF) announced a unique partnership to develop therapeutic treatments for people with type I diabetes at different stages of the disease – both those living with the disease and the newly diagnosed – as well as preventing diabetes in those at risk. [Sanofi-aventis Press Release]

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant Human Stem Cells
Sangamo BioSciences, Inc. announced the publication of data demonstrating the preclinical efficacy of a human stem cell therapy for human immunodeficiency virus (HIV) based on its proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. [Sangamo BioSciences, Inc. Press Release]

Excelimmune Garners $4.5 Million in New Financing
Excelimmune has rounded up $4.5 million in new financing for its planned clinical development work on polyclonal antibodies. [FierceBiotech]


Research Budgets Face Austerity in 2012
The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States]

The Reality of Human Stem Cell Research in Europe
A new report from the European Science Foundation examines the key scientific questions for human stem cell research in the context of the rapidly emerging field of regenerative medicine. [European Science Foundation, European Union]

AstraZeneca Loses Generic Drug Case versus EU A European Union (EU) court backed an EU antitrust decision against Anglo-Swedish drug maker AstraZeneca, lending weight to a regulatory crackdown on firms blocking cheaper drugs coming to market. [The General Court, European Union]

Strong Medicine for French Research The medical-research adviser to France’s president aims to shift power and money to universities. [National Research Agency, France]

Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States]

Maryland Stem Cell Research Commission – Public Meeting Notice [Maryland Stem Cell Research Commission, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Science Board Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001]  [Food and Drug Administration, United States]

Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics [Food and Drug Administration, United States]

Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval Applications [Docket Nos. FDA-2010-M-0068, FDA-2010-M-0078, FDA-2010-M-0063, FDA-2010-M-0135, FDA-2010-M-0158] [Food and Drug Administration, United States]

Webinar on FDA’s Safety Monitoring of Approved Vaccines [Food and Drug Administration, United States]


The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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