Volume 2.24 | Jul 2

Immune Regulation News 2.24, July 2, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Surprising Find May Yield New Avenue of Treatment for Painful Herniated Discs  ShareThis
An immune cell known to cause chronic inflammation in autoimmune disorders has been identified as a possible culprit in low back pain associated with herniated discs, according to doctors. [Press release from Duke University Medical Center discussing online prepublication in Arthritis and Rheumatism]

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A One-Two Punch: Embryonic Cell and Adult Pig Islet Transplants Cure Diabetes in Rats
In a step toward curing diabetes in humans, scientists have alleviated diabetes in rats using transplants from both embryonic and adult pigs. [Press release from the Washington University School of Medicine in St. Louis discussing online prepublication in the American Journal of Pathology]

Early Exposure to Cow’s Milk has Benefits: Study
A taste of cow’s milk during the first two weeks of life may protect a child from later developing an allergy to the milk’s protein, a new study suggests. [Reuters News Press Release]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Transcription Factor MafB Antagonizes Antiviral Responses by Blocking Recruitment of Coactivators to the Transcription Factor IRF3
Higher expression of transcription factor MafB in human pancreatic islet beta cells might increase cellular vulnerability to viral infections associated with the etiology of type I diabetes. [Nat Immunol]

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones
Here, researchers showed that upon T cell activation, the proapoptotic molecule Noxa (encoded by Pmaip1) and its antagonist Mcl-1 were induced. [Immunity]

Interleukin-1(Beta) Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue
Researchers demonstrate that the IL-1 receptor IL-1R1 was selectively expressed by a subpopulation of immature natural killer cells that localized proximal to IL-1(beta)-producing conventional dendritic cells within secondary lymphoid tissue. [Immunity]

Eosinophil Differentiation in the Bone Marrow is Inhibited by T Cell-Derived IFN(Gamma)
Researchers found that CD70-transgenic (CD70TG) mice, which have elevated numbers of IFN(gamma)-producing effector T cells in the periphery and bone marrow, are almost devoid of eosinophilic granulocytes. [Blood]

Endogenous Dendritic Cells Mediate the Effects of Intravenously Injected Therapeutic Immunosuppressive Dendritic Cells in Transplantation
Using prototypic in vitro -generated maturation-resistant dendritic cells (MR-DCs), researchers demonstrate that once MR-DCs carrying donor-antigen are administered i.v., they decrease the direct and indirect pathway T cell responses and prolong heart allograft survival, but fail to directly regulate T cells in vivo. [Blood]

IL-17 Immunity in Human Type I Diabetes
In this study, researchers show upregulation of Th17 immunity in peripheral blood T cells from children with type I diabetes. [J Immunol]

Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope
Researchers conclude that the shared epitope acts as a potent immune-stimulatory ligand that can polarize T cell differentiation toward Th17 cells, a T cell subset that was recently implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis. [J Immunol]

Four and a Half LIM Domain Protein 2 Is a Novel Regulator of Sphingosine 1-Phosphate Receptor 1 in C-C Motif Chemokine Ligand 19-Induced Dendritic Cell Migration
Results identify four and a half LIM domain protein 2 as an important novel regulator of dendritic cell migration via regulation of their sensitivity toward environmental migratory cues like sphingosine 1-phosphate and CCL19. [J Immunol]

Engraftment of Cells from Porcine Islets of Langerhans and Normalization of Glucose Tolerance Following Transplantation of Pig Pancreatic Primordia in Nonimmune-Suppressed Diabetic Rats
Here, in rats transplanted previously with E28 pig pancreatic primordia in the mesentery, researchers show normalization of glucose tolerance in nonimmune-suppressed streptozotocin-diabetic LEW rats and insulin and porcine proinsulin mRNA-expressing cell engraftment in the kidney following implantation of porcine islets beneath the renal capsule. [Am J Pathol]

Independence of Exogenous Insulin Following Immunoablation and Stem Cell Reconstitution in Newly Diagnosed Diabetes Type I
Researchers conclude that at least temporary independence of exogenous insulin can be achieved in type I diabetes patients following immunoablation and reconstitution of the immune system with autologous PBSCs. [Bone Marrow Transplant]


Tolerx Initiates Confirmatory Phase III Clinical Trial, DEFEND-2, with Otelixizumab for Type I Diabetes
Tolerx, Inc. announced the initiation of a confirmatory Phase III clinical trial to further evaluate otelixizumab in autoimmune new-onset type I diabetes. [Tolerx, Inc. Press Release]

Phadia Receives FDA 510 (k) Clearance for EliA APS Tests
Phadia is pleased to announce that it has received U.S. Food and Drug Administration (FDA) 510 (k) clearance for EliA Cardiolipin and EliA (Beta)2-Glycoprotein I (both IgG and IgM) assays for the detection of autoantibodies to aid in the diagnosis of the Antiphospholipid Syndrome. [Phadia AB Press Release]

OHSU Knight Cancer Institute Among First in Nation to Treat Prostate Cancer Patients With New Immunotherapy
The Oregon Health & Science University Knight Cancer Institute will be among the first sites in the nation to treat advanced prostate cancer patients with the newest drug approved by the FDA to fight the disease. [OHSU Knight Cancer Institute Press Release]

CEL-SCI Collaborator Presents Data Showing LEAPS Vaccine Technology Generates Dendritic Cells That Can Protect Animals Against Viral Illness and Other Diseases
CEL-SCI Corporation and researchers at the Northeastern Ohio Universities Colleges of Medicine and Pharmacy jointly announced that a LEAPS(TM)-based vaccine (Ligand Epitope Antigen Presentation System) study has demonstrated the technology’s potential using dendritic cells to stimulate the immune system to fight viral illnesses and other diseases. [CEL-SCI Corporation Press Release]


FDA Approves Rapid Test for Antibodies to Hepatitis C Virus
The U.S. Food and Drug Administration announced approval of the first rapid blood test for antibodies to the hepatitis C virus (HCV) for individuals 15 years and older. [Food and Drug Administration, United States]

NIBIB and the Indian Department of Biotechnology Collaborate to Develop Low-Cost Medical Devices
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) announced the availability of supplemental funding for eligible NIBIB-supported research grants to facilitate collaborative work among researchers in the United States and India. [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Amendment: PAR-09-103: Centers for AIDS Research and Developmental Centers for AIDS Research (P30) (NOT-AI-10-033) [National Institutes of Health, United States]

Extension of Expiration Date and Additional Receipt Dates for RFA-AI-10-014: Ancillary Studies in Immunomodulation Clinical Trials (R01) (NOT-AI-10-035)  [National Institutes of Health, United States]

Development of Articles for Rare Diseases [Food and Drug Administration, United States]


The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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