Volume 2.23 | Jun 25

Immune Regulation News 2.23, June 25, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Gut-Residing Bacteria Trigger Arthritis in Genetically-Susceptible Individuals
A single species of bacteria that lives in the gut is able to trigger a cascade of immune responses that can ultimately result in the development of arthritis. [Press release from Harvard Medical School discussing online prepublication in Immunity]

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SCIENCE NEWS

Why Do Certain Diseases Go Into Remission During Pregnancy?
During pregnancy, many women experience remission of autoimmune diseases like multiple sclerosis and uveitis. Now, scientists have described a biological mechanism responsible for changes in the immune system that helps to explain the remission. [Press release from the University of Michigan discussing online prepublication in the American Journal of Reproductive Immunology]

Insulin Peptide May Point to Solution for Type 1 Diabetes
Researchers have identified the precise protein fragment, or peptide, that can trigger diabetes in mice. [Press release from National Jewish Health discussing online prepublication in Proceedings of the National Academy of Sciences USA]

Blood Deficiencies are Strong Predictors of Poor Outcome
For healthcare professionals diagnosing primary Sjögren’s Syndrome, the incidence of blood based deficiencies is the strongest predictor of a poor outcome in patients according to the results of a study presented at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy. [Press release from EurekAlert! discussing research presented at the Annual Congress of the European League Against Rheumatism in Rome (EULAR 2010)]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Researchers report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free conditions, accompanied by reductions in serum autoantibody titers, splenic autoantibody-secreting cells, germinal centers, and the splenic T helper 17 cell population. [Immunity]

Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation
Using chromatin immunoprecipitation and massive parallel sequencing, researchers quantitated the full complement of STAT-bound genes, concurrently assessing global STAT-dependent epigenetic modifications and gene transcription by using cells from cognate STAT-deficient mice. [Immunity ]

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones
Here researchers showed that upon T cell activation, the proapoptotic molecule Noxa (encoded by Pmaip1) and its antagonist Mcl-1 were induced. [Immunity]

Revised Map of the Human Progenitor Hierarchy Shows the Origin of Macrophages and Dendritic Cells in Early Lymphoid Development
Here researchers provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. [Nat Immunol]

Inducible Foxp3+ Regulatory T Cell Development by a Commensal Bacterium of the Intestinal Microbiota
Researchers report that a prominent human commensal, Bacteroides fragilis, directs the development of Foxp3+ regulatory T cells with a unique “inducible” genetic signature. [Proc Natl Acad Sci U S A]

Exploiting Cross-Priming to Generate Protective CD8 T Cell Immunity Rapidly
Here, researchers demonstrate that in vivo cross-priming with cell-associated antigens or antigen-coated, biodegradable microspheres in the absence of adjuvant quickly generates CD8 T cells that display the phenotype and function of long-term memory populations. [Proc Natl Acad Sci U S A]

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells
Researchers studied the role of TNF in the induction of antigen-specific regulatory T cells by tolerogenic vitamin D3-modulated human dendritic cells, which previously were shown to release high amounts of soluble TNF upon maturation with LPS. [J Immunol]

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
To investigate the role of nucleotide-binding domain, leucine-rich repeat containing protein family, pyrin domain containing 3 (NLRP3) protein in multiple sclerosis (MS), researchers used a mouse model of MS, experimental autoimmune encephalomyelitis. [J Immunol]

Altered Effector CD4+ T Cell Function in IL-21R-/- CD4+ T Cell-Mediated Graft-Versus-Host Disease
It was previously shown that transplantation with IL-21R gene-deficient splenocytes resulted in less severe graft-versus-host disease than was observed with wild type splenocytes. In this study, researchers sought to find mechanism(s) explaining this observation. [J Immunol]

Tumor Cells Engineered to Codisplay on Their Surface 4-1BBL and LIGHT Costimulatory Proteins as a Novel Vaccine Approach for Cancer Immunotherapy
Researchers herein demonstrate that TC-1 tumor cells can be rapidly and efficiently engineered to codisplay on their surface two costimulatory proteins, SA-4-1BBL and SA-LIGHT, simultaneously. [Cancer Gene Ther]

Leukocyte Pyruvate Kinase Expression is Reduced in Normal Human Pregnancy but not in Pre-Eclampsia
To examine the immunoregulatory role of glycolysis in pregnancy, researchers evaluated the properties of pyruvate kinase in leukocytes from non-pregnant women and those with normal pregnancy and pre-eclampsia. [Amer J Reprod Immunol]


INDUSTRY NEWS

CIRM Allocates $25 Million to Overcome Immune Rejection of Stem Cell Transplantation Therapies
The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved $25 million to fund 19 projects intended to overcome immune rejection of transplanted stem cells. [California Institute for Regenerative Medicine Press Release]

Lupus Research Institute Underscores Urgent Need for Research in Pediatric Lupus at International Lupus Congress
The Lupus Research Institute National Coalition of state and local lupus groups, alarmed at the crucial need for answers to the devastating effects of lupus when diagnosed in the young, is sponsoring key programming in lupus pediatrics at the International Lupus Congress in Vancouver. [Lupus Research Institute Press Release]

Anthera Enrolls First Patients in Pivotal Varespladib Phase III Clinical Study
Anthera Pharmaceuticals, Inc. announced patient enrollment has commenced in the Company’s pivotal VISTA-16 (Vascular Inflammation Suppression to Treat Acute Coronary Syndrome for 16 Weeks) Phase III clinical study of varespladib (A-002). [Anthera Pharmaceuticals, Inc. Press Release]

Tolera Therapeutics Granted Orphan Drug Designation For Treatment Of Type I Diabetes Mellitus
Tolera Therapeutics, Inc., was granted orphan drug status by the United States Food and Drug Administration for TOL101 (anti-TCR murine monoclonal antibody, type IgM), for treatment of recent onset immune-mediated Type I diabetes mellitus. [Tolera Therapeutics Inc. Press Release]



POLICY NEWS

Hospital Clínic de Barcelona Obtained the First Accreditation for Cell Therapy Research
The certification, awarded for the first time in Catalonia, allows the Hospital Clínic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain]

New Videos Reveal How NIH Identifies the Most Promising Research Applications
The National Institutes of Health’s Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States]

NIH and Wellcome Trust Announce Partnership to Support Genomic, Population-Based Studies in Africa
The National Institutes of Health (NIH) and the Wellcome Trust announced a partnership with African researchers to conduct genetic and environmental studies in Africa of common, non-communicable disorders, such as heart disease and cancer, as well as communicable diseases, such as malaria. [National Institutes of Health, United States]

Publication of New Enforcement Strategy
A new enforcement strategy has been published by the Inspection, Enforcement and Standards Division. [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

FDA/CDRH Public Meeting: Oversight of Laboratory Developed Tests (LDTs), Date July 19-20, 2010 [Food and Drug Administration, United States]

Drugs Designated as Orphan Drugs [Therapeutic Goods Administration, Australia]

Therapeutic Goods Committee (TGC) (Updated) [Therapeutic Goods Administration, Australia]


EVENTS

The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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