Volume 2.22 | Jun 18

Immune Regulation News 2.22, June 18, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Gene Linked to Autoimmune Diseases
Differences in the sequence of a single gene may be partly responsible for causing around 2% of relatively common autoimmune disorders including diabetes and arthritis. [Press release from the Nature News discussing online prepublication in Nature]

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SCIENCE NEWS

Virus Infection May Trigger Unusual Immune Cells to Attack the Brain and Spinal Cord in Multiple Sclerosis
A virus infection can incite the body to attack its own nerve tissue by activating rare, disease-fighting cells with receptors for both viral and nerve proteins. [Press release from the University of Washington discussing online prepublication in Nature Immunology]

Scientists Begin to Unravel Causes of Mysterious Skin Disease
Scientists have discovered additional evidence that generalized vitiligo – a disease that typically causes patches of white skin on the face, neck and extremities that pop star Michael Jackson may have experienced – is associated with slight variations in genes that play a role in the body’s natural defenses. [Press release from the University of Florida discussing online prepublication in Nature Genetics]

Alcohol Consumption Lowers Risk of Developing Several Arthrotic Conditions
Alcohol consumption is associated with a significantly reduced risk of developing several arthritic conditions including Rheumatoid Arthritis, Osteoarthritis, reactive arthritis, psoriatic arthritis and spondylarthropathy, according to results of a new study. [European League Against Rheumatism (EULAR) Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Functionally Defective Germline Variants of Sialic Acid Acetylesterase in Autoimmunity
Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders. [Nature]

Viral Infection Triggers Central Nervous System Autoimmunity via Activation of CD8+ T Cells Expressing Dual TCRs
Here researchers found that CD8+ myelin basic protein (MBP)-specific T cell tolerance was broken and autoimmunity was induced by infection with a virus that did not express MBP cross-reactive epitopes and did not depend on bystander activation. [Nat Immunol]

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets Via Distinct Signaling Pathways
Researchers showed that conditional deletion of rictor, an essential subunit of mTORC2, impaired differentiation into T helper 1 and T helper 2 cells without diversion into FoxP3+ status or substantial effect on Th17 cell differentiation. [Immunity]

Monocytic Suppressive Cells Mediate Cardiovascular Transplantation Tolerance in Mice
The results suggest that mobilization of bone marrow CD11b+CD115+Gr1+ monocytes under sterile inflammatory conditions mediates the induction of indefinite allograft survival. [J Clin Invest]

PD-L1 has Distinct Functions in Hematopoietic and Nonhematopoietic Cells in Regulating T Cell Responses During Chronic Infection in Mice
Here researchers used bone marrow chimeric mice to examine the effects of PD-L1 deficiency in hematopoietic or nonhematopoietic cells during lymphocytic choriomeningitis virus clone 13 (LCMV CL-13) infection. [J Clin Invest]

The Endocytic Adaptor Numb Regulates Thymus Size by Modulating Pre-TCR Signaling During Asymmetric Division
Researchers found that Numb determines the levels of pre-TCR signaling in dividing thymocytes and, ultimately, the size of the pool from which mature T lymphocytes are selected. [Blood]

Notch 1 as a Potential Therapeutic Target in Cutaneous T Cell Lymphoma
By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sezary syndrome researchers demonstrated prominent expression of Notch1 on tumor cells, especially in the more advanced stages. [Blood]

Platelet Transcriptional Profile and Protein Expression in Patients with Systemic Lupus Erythematosus: Up-Regulation of the Type I Interferon System is Strongly Associated with Vascular Disease
Researchers used microarray to probe the platelet transcriptome in individuals with systemic lupus erythematosus and healthy controls, and the gene and protein expression of a subset of differentially expressed genes was further investigated and correlated to platelet activation status. [Blood]

Thymic Stromal Lymphopoietin from Trophoblasts Induces Dendritic Cell-Mediated Regulatory TH2 Bias in the Decidua During Early Gestation in Humans
In this study researchers found that human trophoblasts and decidual epithelial cells in maternal-fetal interface of early placentas express thymic stromal lymphopoietins mRNA and protein, but only trophoblast cells secret soluble TSLP. [Blood]

Human Fibroblasts Support the Expansion of IL-17 Producing T Cells Via Up-Regulation of IL-23 Production by Dendritic Cells
Since researchers have shown that dendritic cells (DCs) interact with fibroblasts during immune responses they studied the impact of skin fibroblasts on human monocyte-derived DC function and subsequent human T cell differentiation. [Blood]

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17Beta-Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts
In this report, researchers show that cancer-associated fibroblasts respond to physiologic concentrations of 17beta-estradiol (E2) by rapidly inducing extracellular signal-regulated kinase phosphorylation and immediate early gene expression, including c-fos and connective tissue growth factor, and cyclin D1. [Cancer Res]


INDUSTRY NEWS

SymBio Pharmaceuticals and Cephalon Conclude License Agreement to Develop Drug for Systemic Lupus Erythematosus in Japan
SymBio Pharmaceuticals Limited announced that it has concluded a license agreement with a Swiss affiliate of US-based Cephalon, Inc., for the development of Rigerimod (also known as Lupuzor™) in Japan, a product candidate for the treatment of Systemic Lupus Erythematosus. [SymBio Pharmaceuticals Ltd. Press Release]

U.S. Biotech Firms Line Up for Tax Credits
Starting on 21 June, many small biotech companies will be racing to take advantage of a tax credit worth up to $5 million per company and totaling $1 billion as part of the Therapeutic Discovery Project Program. [NatureNews Press Release]


POLICY NEWS

NICE Final Draft Guidance Recommends Improved Access to Psoriatic Arthritis Treatments
Etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) are proposed for treating adults with active and progressive psoriatic arthritis when specified criteria are met. [National Institute of Health and Clinical Excellence, United Kingdom]

The Path to Personalized Medicine
The leaders of the National Institutes of Health and the Food and Drug Administration have a shared vision of personalized medicine and the scientific and regulatory structure needed to support its growth. Together, they have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. [Food and Drug Administration and the National Institutes of Health, United States]

FDA Takes Issue with Genetic Tests from 23andMe, Four Other Firms
The Food and Drug Administration has put five genetic test makers on notice that they must get federal approval before marketing their products for use by consumers. [Food and Drug Administration, United States]

Diseased Cells Fail to Win Approval In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for US federal funding, a National Institutes of Health (NIH) committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States]

NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States]

Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-Study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

Clinical Trials for Medicines Section Updated [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Advertising and Supply of Therapeutic Goods to Complementary Healthcare Professionals: Schedule 1 to the Therapeutic Goods Regulations [Therapeutic Goods Administration, Australia]

Increased Transparency of the Prescription Medicine Regulatory Process [Therapeutic Goods Administration, Australia]


EVENTS

Phacilitate Vaccine & Immunotherapy Forum 2010
June 21-23, 2010
Barcelona, Spain

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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