Volume 2.20 | Jun 4

Immune Regulation News 2.20, June 4, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Immune Cell’s Role in Lupus Nephritis Demonstrated, Paves Way for Safety Testing of Potential New Use for Asthma Drug
National Institutes of Health scientists have discovered that the activation of basophils causes kidney damage in a mouse model of lupus nephritis. [Press release from the National Institutes of Health discussing online prepublication in Nature Medicine]

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SCIENCE NEWS

Study of MicroRNA Helps NIH Scientists Unlock Secrets of Immune Cells
Researchers with the National Institutes of Health are closer to understanding how activity outside of the nucleus determines a cell’s behavior. They looked at mouse immune cells and examined the types, amount, and activity of microRNAs. [Press release from the National Institutes of Health discussing online prepublication in Immunity]

Immune System Helps Transplanted Stem Cells Navigate in Central Nervous System
By discovering how adult neural stem cells navigate to injury sites in the central nervous system, UC Irvine researchers have helped solve a puzzle in the creation of stem cell-based treatments: How do these cells know where to go? [Press release from the University of California, Irvine discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Targeted Immunotherapy Shows Promise in Penn Medicine Studies for Metastatic Breast and Pancreatic Cancers
Early trials using targeted monoclonal antibodies in combination with existing therapies show promise in treating pancreatic cancer and metastatic breast cancer, according to research. [Press release from the University of Pennsylvania discussing research to be presented at the American Society of Clinical Oncology Annual Meeting]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Basophils and the T Helper 2 Environment can Promote the Development of Lupus Nephritis
Researchers report that activation of basophils by autoreactive IgE causes their homing to lymph nodes, promoting T helper type 2 cell differentiation and enhancing the production of self-reactive antibodies that cause lupus-like nephritis in mice lacking the Src family protein tyrosine kinase Lyn (Lyn-/- mice). [Nat Med]

Semaphorins Guide the Entry of Dendritic Cells into the Lymphatics by Activating Myosin II
Here researchers show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells into the lymphatics. [Nat Immunol]

Regulation of MicroRNA Expression and Abundance During Lymphopoiesis
Researchers applied miRNA-, mRNA-, and ChIP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome and epigenome. [Immunity]

The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner
Here researchers showed that PU.1 (encoded by Sfpi1) was essential for dendritic cell (DC) development in vivo and that conditional ablation of PU.1 in defined precursors, including the common DC progenitor, blocked Flt3 ligand-induced DC generation in vitro. [Immunity]

CD62L Expression Identifies a Unique Subset of Polyfunctional CD56(dim) NK Cells
Human Natural Killer (NK) cells comprise two main subsets, CD56(bright) and CD56(dim) cells, that differ in function, phenotype and tissue localization. To further dissect the heterogeneity of CD56(dim) cells, researchers have performed transcriptome analysis and functional ex vivo characterization of human NK cell subsets according to the expression of markers related to differentiation, migration or competence. [Blood]

Immune Monitoring with iTAg(TM) MHC Tetramers for Prediction of Recurrent or Persistent Cytomegalovirus (CMV) Infection or Disease in Allogeneic Hematopoietic Stem Cell Transplant (HCT) Recipients: A Prospective Multicenter Study
Researchers evaluated the use of HLA Class I tetramers in monitoring CMV-specific T cell recovery to predict patients at risk for CMV-related complications. [Blood]

PGE(2) Transiently Enhances DC Expression of CCR7 but Inhibits the Ability of DCs to Produce CCL19 and Attract Naive T Cells
Here, researchers show that high surface expression of CCR7 on PGE(2)-matured dendritic cells (DCs) is associated with their suppressed production of the endogenous CCR7-ligand, CCL19, and is reversible by exogenous CCL19. [Blood]

Migration of Engrafted Neural Stem Cells is Mediated by CXCL12 Signaling Through CXCR4 in a Viral Model of Multiple Sclerosis
Researchers have used a model of viral-induced demyelination to characterize signaling cues associated with positional migration of transplanted remyelination-competent cells. [Proc Natl Acad Sci U S A]

Control of T Cell Reactivation by Regulatory Qa-1-Restricted CD8+ T Cells
Researchers hypothesized that vaccination with natural killer T (NKT) cells could also induce Qa-1-restricted CD8+ T cells that would control NKT cell activation. [J Immunol]

Regulation of Cytokine-Driven Functional Differentiation of CD8 T Cells by Suppressor of Cytokine Signaling 1 Controls Autoimmunity and Preserves Their Proliferative Capacity Toward Foreign Antigens
In this study, researchers examined whether CD8 T cells that accumulate in suppressor of cytokine signaling 1 (SOCS1)-deficient mice because of increased IL-15 signaling in vivo would respond to an autoantigen expressed at a very low level using a mouse model of autoimmune diabetes. [J Immunol]


INDUSTRY NEWS

Dendreon Announces Presentation of PROVENGE Data at the American Urological Association Annual Meeting
Dendreon Corporation announced the presentation of safety data from the integrated analysis of four randomized PROVENGE® (sipuleucel-T) clinical trials of an autologous cellular immunotherapy in prostate cancer at the 105th Annual Scientific Meeting of the American Urological Association (AUA) in San Francisco. [Dendreon Corporation Press Release]

ProImmune Launches DC-T Cell Proliferation Assay for Immunogenicity Assessment of Whole Proteins
ProImmune Ltd., has launched DC-T Cell Proliferation Assays based on its class-leading CFSE detection platform to assess the immunogenicity of whole proteins. [ProImmune Ltd. Press Release]

Selecta Biosciences, Inc. Closes $15 Million Series C Financing
Selecta Biosciences, Inc. announced that it has raised $15 million in a Series C financing round. [Selecta Biosciences, Inc. Press Release]

Immunotherapy for Tumors Key Topic at Cancer Meeting
New compounds designed to harness the body’s own immune system against tumors will be a focus of the biggest annual cancer meeting this week, where drugmakers will issue clinical data on hundreds of treatments. [Reuters]


POLICY NEWS

Treasury Releases New Guidance for Tax Credit in Affordable Care Act to Support Groundbreaking Biomedical Research
The U.S. Department of the Treasury announced the guidelines for applying for the new Therapeutic Discovery Project Program created by the Affordable Care Act. [Department of the Treasury, United States]

Third Time’s a Charm for COMPETES Bill
By a vote of 262 to 150, legislators authorized $84 billion for research, education, and innovation programs over the next 5 years at the National Science Foundation, the Department of Energy, and two Department of Commerce agencies – NOAA and NIST under the America COMPETES Reauthorization Act (HR 5116). [House of Representatives, United States]

Democrats: FDA Should Be Able to Recall Drugs
House Democrats repeatedly called for federal regulators to be given the authority to recall drugs. Pending legislation would grant that power to the Food and Drug Administration (FDA) for food, but not for drugs. [House of Representatives, United States]

Congress Considers Synthetic Biology Risks, Benefits
Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said that the government is moving quickly to bring synthetic biology under review by two existing panels that have done a good job of monitoring cutting-edge research in the past. [House of Representatives Committee on Energy and Commerce, United States]

Last Hurrah from National Academies Stem Cell Committee
Even though the National Institutes of Health issued stem cell guidelines last year, there’s still a need for guidelines for research that remains off-limits for U.S. government-funded labs. [National Academies’ National Research Council and Institute of Medicine, United States]

NIH Set to Tighten Financial Rules for Researchers
After a wave of financial scandals over the past few years involving biomedical researchers, the U.S. National Institutes of Health (NIH) proposed far-reaching changes that would lead to tighter oversight of agency-funded extramural investigators and their institutions. [National Institutes of Health, United States]

Request for Information (RFI) on the NIH Plan to Develop the Genetic Testing Registry (NOT-OD-10-101) [National Institutes of Health, United States]

Administrative Supplements to Advance Special Translational Research Acceleration Projects on Immune Response Modifiers Currently Funded by the National Cancer Institute (NCI) (NOT-CA-10-025) [National Institutes of Health, United States]


EVENTS

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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