Volume 2.19 | May 28

Immune Regulation News 2.19, May 28, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Rare Hybrid Cell Key to Regulating the Immune System
A cell small in number but powerful in its ability to switch the immune system on or off is a unique hybrid of two well-known immune cell types, researchers report. [Press release from the Medical College of Georgia discussing online prepublication in the Proceedings of the National Academy of Sciences]

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When Helper Cells Aren’t Helpful
Current research suggests that T helper-type 1 (Th1) cells, previously thought to mediate autoimmunity, may actually inhibit the development of experimental immune encephalomyelitis, a mouse model of multiple sclerosis, by suppressing Th17 cells. [Press release from Biocompare discussing online prepublication in the American Journal of Pathology]

Transplant Tolerance ‘Signature’ Identified
A team of researchers have identified a ‘full set’ of immunological markers in the blood, which could be used to predict whether an individual’s kidney transplant will be a long term success or whether it will fail. [Press release from the King’s College London discussing online prepublication in the Journal of Clinical Investigation]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The T Helper Type 2 Response to Cysteine Proteases Requires Dendritic Cell-Basophil Cooperation via ROS-Mediated Signaling
Here researchers demonstrate that cysteine protease-induced TH2 responses occur via ‘cooperation’ between migratory dermal dendritic cells and basophils positive for interleukin 4. [Nat Immunol]

A Molecular Classifier for Predicting Future Graft Loss in Late Kidney Transplant Biopsies
To assess the kidney upon developing signs of renal dysfunction or proteinuria, a “for-cause” biopsy is performed, but this provides little indication as to which recipients will go on to organ failure. In an attempt to identify molecules that could provide this information, researchers used micorarrays to analyze gene expression in 105 for-cause biopsies taken between 1 and 31 years after transplantation. [J Clin Invest]

Grb2 Functions at the Top of the T Cell Antigen Receptor-Induced Tyrosine Kinase Cascade to Control Thymic Selection
Here researchers show that conditional ablation of Grb2 in thymocytes severely impairs both thymic positive and negative selections. [Proc Natl Acad Sci U S A]

B Lymphoid Cells with Attributes of Dendritic Cells Regulate T Cells Via Indoleamine 2,3-Dioxygenase
Here researchers show that indoleamine 2,3-dioxygenase-competent cells express the B lineage commitment factor Pax5 and surface immunoglobulins. [Proc Natl Acad Sci U S A]

Immature Immunosuppressive CD14+HLA-DR(-/low) Cells in Melanoma Patients are Stat3(hi) and Overexpress CD80, CD83, and DC-Sign
In this study, researchers have examined circulating CD14+HLA-DR(-/low) myeloid-derived suppressor cells in 34 advanced malignant melanoma patients. [Cancer Res]

Immune Infiltration of Spontaneous Mouse Astrocytomas Is Dominated by Immunosuppressive Cells from Early Stages of Tumor Development
Overall, the results show an early defective endogenous immune response to gliomas, and local accumulation of immunosuppressive cells at the tumor site. [Cancer Res]

Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels
In this report, researchers provide evidence that ATP, the energy molecule and signal element, accounts for the selective depletion of regulatory T cells by low-dose cyclophosphamide. [Cancer Res]

Control of T Cell Reactivation by Regulatory Qa-1-Restricted CD8+ T Cells
These experiments provide new insight into a CD8+ T cell compartment that regulates the immediate reactivation of conventional T cells and natural killer T cells. [J Immunol]


Oncolytic Viruses Mediating Anti-Tumor Immunity in Human Cancer Patients Published by Oncos Therapeutics and University of Helsinki
Oncos Therapeutics published initial results from its Advanced Therapy Access Program in Cancer Research. [Oncos Therapeutics Press Release]

HemaCare Announces First Commercial Cell Therapy Collection Agreement
HemaCare Corporation announced an agreement with Dendreon Corporation to provide cellular collection services in Los Angeles and Maine for their new autologous cellular immunotherapy, PROVENGE® (sipuleucel-T). [HemaCare Corporation Press Release]

Maryland Stem Cell Research Commission Announces 42 Projects for Funding
The Maryland Stem Cell Research Commission has completed its evaluation of the 141 applications in response to its three official Requests for Applications during the FY 2010 funding cycle. [Maryland Stem Cell Research Commission Press Release]

HHMI Awards $79 Million for Science Education to Research Universities, Top Scientists
Howard Hughes Medical Institute (HHMI) announced new grants totaling $79 million that will help universities strengthen undergraduate and precollege science education nationwide. [Howard Hughes Medical Institute Press Release]

Rensselaer Polytechnic Institute Wins $2.45 Million Grant To Support Stem Cell Research
Rensselaer Polytechnic Institute and principal investigator Glenn Monastersky have been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program of the Empire State Stem Cell Board. [Rensselaer Polytechnic Institute Press Release]

California’s Immune Tolerance Institute Plans Center at N.C. Research Campus
The Immune Tolerance Institute is expected to announce plans for the Center for Critical Path Research in Immunology. [Charlotte Business Journal]


NIH Wants More (Not Total) Disclosure of Financial Conflicts
The federal government proposed an overhaul of regulations covering financial conflicts of interest in biomedical research. [National Institutes of Health, United States]

NIH Requests Comments on the Proposed Rule Applicable to Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-10-099) [National Institutes of Health, United States]

NIH Requests Comments on the Proposed Rule Applicable to Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-10-099) [National Institutes of Health, United States]

Notice of Format Clarification and Frequently Asked Questions (FAQs) for Funding Opportunity Announcement (FOA): RFA-HL-11-006, Next Generation Genetic Association Studies (U01) (NOT-HL-10-110) [National Institutes of Health, United States]

Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors; Proposed Rule (Docket Number: NIH-2010-0001) [National Institutes of Health, United States]

Administrative Supplements to Advance Special Translational Research Acceleration Projects on Immune Response Modifiers Currently Funded by the National Cancer Institute (NCI) (NOT-CA-10-025) [National Cancer Institute]

Charter of the Blood Products Advisory Committee (Update) [Food and Drug Administration, United States]

FDA Transparency Initiative: Draft Proposals for Public Comment Regarding Disclosure Policies of the U.S. Food and Drug Administration; Availability [Docket No. FDA-2009-N-0247] [Food and Drug Administration, United States]


29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select BioSciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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