Volume 2.18 | May 21

Immune Regulation News 2.18, May 21, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation
Here, researchers generated and analyzed GRAIL-deficient mice and found they were resistant to immune tolerance induction and exhibited greater susceptibility to autoimmune diseases than wild-type mice. [Immunity]

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SCIENCE NEWS

Australian Researchers Identify a New Disease
Researchers have identified a previously undiagnosed condition and successfully treated it by performing an experimental stem cell transplant. [Press release from the Queensland Institute of Medical Research discussing online prepublication in Clinical Infectious Diseases]

Scientists Identify Mechanism T Cells Used To Block HIV
Scientists have found a new role for a host protein that provides further insight into how CD8+ T cells work to control HIV and other infections. [Press release from Biocompare discussing online prepublication in Proceedings of the National Academy of Sciences]

High-Fat Meals a No-No for Asthma Patients, Researchers Find
Individuals with asthma who consumed a high-fat meal showed increased airway inflammation just hours after the binge, according to Australian researchers who conducted the study. [Press release from ScienceDaily discussing research presented at the ATS 2010 International Conference]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

PD-1 Regulates Germinal Center B cell Survival and the Formation and Affinity of Long-Lived Plasma Cells
Because follicular helper T cells have high expression of the immunoinhibitory receptor PD-1, researchers investigated the role of PD-1 signaling in the humoral response. [Nat Immunol]

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
Using a T cell transfer model of colitis, researchers found that STAT3 expression in T cells was essential for the induction of both colitis and systemic inflammation. [Immunity]

B7-H1/CD80 Interaction is Required for the Induction and Maintenance of Peripheral T Cell Tolerance
Researchers report here that attenuation of B7-H1/CD80 signals by treatment with anti-B7-H1 monoclonal antibody, which specifically blocks B7-H1/CD80 but not B7-H1/PD-1, enhanced T cell expansion and prevented T cell anergy induction. [Blood]

Transplantation of Allogeneic Hematopoietic Stem Cells for Adult T Cell Leukemia: A Nationwide Retrospective Study
Allogeneic hematopoietic stem cell transplantation using currently available graft source is an effective treatment in selected patients with adult T cell leukemia, although greater effort is warranted to reduce treatment-related mortality. [Blood]

Fulminant Infectious Mononucleosis and Recurrent Epstein-Barr Virus Reactivation in an Adolescent
Researchers describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. [Clin Infect Dis]

8-Methoxypsoralen Plus Ultraviolet A Therapy Acts Via Inhibition of the IL-23/Th17 Axis and Induction of Foxp3+ Regulatory T Cells Involving CTLA4 Signaling in a Psoriasis-Like Skin Disorder
To elucidate the molecular action of 8-methoxypsoralen plus UVA, a standard dermatological therapy, researchers used K5.hTGF-(beta)1 transgenic mice exhibiting a skin phenotype and cytokine abnormalities with strong similarities to human psoriasis. [J Immunol]

Carbamylation-Dependent Activation of T Cells: A Novel Mechanism in the Pathogenesis of Autoimmune Arthritis
T cell response to homocitrulline-derived peptides, as well as the subsequent production of anti-homocitrulline antibodies, is critical for the induction of autoimmune reactions against citrulline-derived peptides and provides a novel mechanism for the pathogenesis of arthritis. [J Immunol]

Multiple Mechanisms Downstream of TLR-4 Stimulation Allow Expression of NKG2D Ligands To Facilitate Macrophage/NK Cell Crosstalk
In this paper, researchers clarify that LPS, which ligates TLR-4, preferentially upregulated MICA and not MICB; CL097, which ligates TLR-7/8, upregulated both MICA and MICB; and polyinosinic-polycytidylic acid, which ligates TLR-3, upregulated neither. [J Immunol]

Antigen Quality Determines the Efficiency of Antitumor Immune Responses Generated in the Absence of Regulatory T Cells
Researchers show that the presence of a strong dominant antigen is required for the induction of effector responses capable of tumor eradication in the absence of regulatory T cells. [Cancer Gene Ther]


INDUSTRY NEWS

Ablynx Announces a Third Extension of Its Anti-TNF-Alpha Nanobody Collaboration with Pfizer
Ablynx announced that the research collaboration which forms part of its license agreement for Nanobodies to tumour necrosis factor alpha (TNF-alpha) with Pfizer has been extended for another year. [Ablynx Inc. Press Release]

Biogen, Roche End Arthritis Trial on Safety Issues
Roche and Biogen Idec Inc. said they are discontinuing developing a rheumatoid arthritis drug, several months after the partners suspended drug trials because of patient deaths. [Forbes]


POLICY NEWS

Personal Gene-Testing Companies Need U.S. Clearance, FDA Says
Gene-test kits that promise to tell consumers their risk of Alzheimer’s disease, breast cancer and numerous illnesses must be approved by regulators whether the tests are sold online or in stores, a U.S. official said. [Food and Drug Administration, United States]

NIH Starts to Flesh out Drug Development Program
Lawmakers began discussing the details of a newly created drug development program at the National Institutes of Health (NIH). NIH Director Francis Collins told a Senate panel that he’s eager to get started – once the program has a budget. [National Institutes of Health, United States]

Statement by HHS Secretary Kathleen Sebelius and NIH Director Francis Collins Regarding the President’s Intent to Appoint Dr. Harold Varmus as Director of the National Institute of Cancer at the National Institutes of Health
[National Institutes of Health, United States]

Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network Data Coordinating Center (U10) (NOT-HL-10-108) [National Institutes of Health, United States]

Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

Request for Information: Scientific and Regulatory Issues to be Explored at an Upcoming Pluripotent Stem Cell Workshop Involving NIH and FDA (NOT-NS-10-016) [National Institutes of Health, United States]

Request for Information 75 FR 24835 – Infectious Diseases (Docket No. OSHA-2010-0003) [Food and Drug Administration, United States]

Drug Safety and Risk Management Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes (Docket No. FDA-2010-N-0184) [Food and Drug Administration, United States]


EVENTS

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select BioSciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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