Volume 2.16 | May 7

Immune Regulation News 2.16, May 7, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Single Protein Regulates Two Immune Pathways
A team of researchers has identified a protein called NLRC5, a member of the NOD-like protein family, that is involved in the inhibition of protein complexes key to critical pathways of innate immunity called NF-kappaB and type I interferon signaling. [Press release from Baylor College of Medicine discussing online prepublication in Cell]

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Important Control Mechanism Behind Autoimmune Diseases Discovered
Researchers have discovered a new control mechanism in our immune system. The discovery is of potential significance to the treatment of serious diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. [Press release from Karolinska Institutet discussing online prepublication in The Journal of Experimental Medicine]

Self-Help, Tumors Promote Their Own Metastasis
Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. [Press release from Biocompare discussing online prepublication in The American Journal of Pathology]

FDA Approval of New Prostate Treatment Shows Promise of Cancer Immunotherapy
The U.S. Food and Drug Administration approval of Dendreon’s Provenge® (sipuleucel-T) to treat certain men with advanced prostate cancer marks a significant advance in the development of biological therapy for cancer treatment. [International Society for Biological Therapy of Cancer Press Release]



NLRC5 Negatively Regulates the NF-KappaB and Type I Interferon Signaling Pathways
Here, researchers show that NLRC5, a member of the highly conserved NOD-like protein family, can inhibit the IKK complex and RIG-I/MDA5 function. [Cell]

The Transcription Factor PU.1 is Required for the Development of IL-9-Producing T Cells and Allergic Inflammation
Researchers show that the ETS-family transcription factor PU.1 was required for the development of an interleukin 9-secreting subset of helper T cells. [Nat Immunol]

Autonomous Role of Medullary Thymic Epithelial Cells in Central CD4+ T Cell Tolerance
Their data document an autonomous contribution of medullary thymic epithelial cells to both dominant and recessive mechanisms of CD4+ T cell tolerance and support an avidity model of regulatory T cell development versus deletion. [Nat Immunol]

Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin
To gain insight into the molecular basis of Ebf1 function in early-stage B cells, researchers combined a genome-wide ChIP sequencing analysis with gain- and loss-of-function transcriptome analyses. [Immunity]

Transcription Factors Foxo3a and Foxo1 Couple the E3 Ligase Cbl-B to the Induction of Foxp3 Expression in Induced Regulatory T Cells
This study reveals that Foxo factors promote transcription of the Foxp3 gene in induced regulatory T cells, and thus provides new mechanistic insight into Foxo-mediated T cell regulation. [J Cell Biol]

Invariant NKT Cells Limit Activation of Autoreactive CD1d-Positive B Cells
Here, researchers identify a suppressive role for invariant natural killer T cells in a model where autoantibody production is triggered by an increased load of circulating apoptotic cells, resembling the situation in systemic lupus erythematosus patients. [J Cell Biol]

Treatment of Autoimmune Arthritis Using RNA Interference-Modulated Dendritic Cells
Here, researchers describe the induction of RNA interference through administering short interfering RNA as a means of specifically generating tolerogenic dendritic cells. [J Immunol]

Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3
In this study, researchers have generated a B6 congenic strain harboring the 129 allele of Sle18 and intercrossed this line with the lupus-prone B6.129-Sle16 strain. [J Immunol]

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells
In this study, researchers observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung. Tumor metastasis correlated significantly with an increase in recruitment of more myeloid-derived suppressor cells in the lung of C57BL/6j (B6) mice pretreated with tumor exosomes. [Am J Pathol]


REGiMMUNE to Present Data from Preclinical Study of RGI-2001
REGiMMUNE Corporation presented new preclinical data of the company’s lead product, RGI-2001 (ToleroVax), at the 2010 American Transplant Congress. [REGiMMUNE Corporation Press Release]

ImmunoCellular Therapeutics to Present Clinical Data from ICT-107 at Leading Neurology Conference
ImmunoCellular Therapeutics, Ltd. presented clinical data from ICT-107, the company’s dendritic-cell based cancer vaccine product candidate for the treatment of glioblastoma multiforme, at the 78th American Association of Neurological Surgeons Annual Meeting. [ImmunoCellular Therapeutics, Ltd. Press Release]

Argos Therapeutics Presents Transplantation Data for Soluble CD83 Demonstrating its Ability to Induce Immune Tolerance and Suppress Anti-Donor Antibody Responses
Argos Therapeutics gave two oral presentations detailing data on its soluble CD83 protein program at the 2010 American Transplant Congress. [BusinessWire]


Details of New Wellcome Trust Investigator Awards Announced
The Wellcome Trust announces further details of its Investigator Awards, a major new scheme to support world-class researchers to tackle ambitious research questions about health and disease. [Wellcome Trust Press Release]

Science Panel Cuts Authorization Levels for Three COMPETES Agencies
The House of Representatives Science and Technology Committee scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States]

Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commissioner, European Union]

Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States]

Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 (NOT-AR-10-035) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]

Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]

Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability (Docket No. FDA-2008-D-0263) [Food and Drug Administration, United States]

Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]


29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

The 2nd International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select BioSciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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