Volume 2.13 | Apr 16

Immune Regulation News 2.13, April 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


New Pathway Involved in Rheumatoid Arthritis Identified
Investigators have identified a pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis. [Press release from the Hospital for Special Surgery discussing online prepublication in Immunity]

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New Model Tracks the Immune Response to a T
Using T cells primed for the infectious disease toxoplasmosis, Whitehead Institute researchers have created novel mouse models of the immune system that more accurately reflect how immune cells actually respond to pathogens in their presence. [Press release from Whitehead Institute for Biomedical Research discussing online prepublication in Science]

The Immune System’s Guard Against Cancer
Researchers have discovered how beta-interferon can inhibit tumour growth. [Press release from Helmholtz Center for Infection Research discussing online prepublication in Journal of Clinical Investigation]

BUSPH Study Links Rheumatoid Arthritis To Vitamin D Deficiency
Women living in the northeastern United States are more likely to develop rheumatoid arthritis, suggesting a link between the autoimmune disease and vitamin D deficiency, says a new study. [Press release from Biocompare discussing online prepublication in Environmental Health Perspectives]



Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
Using epigenetic reprogramming via somatic cell nuclear transfer (SCNT), researchers demonstrated that T cells with predefined specificities against Toxoplasma gondii can be used to generate mouse models that express the T cell receptor from their endogenous loci, without experimentally introduced genetic modification. [Science]

The Transcription Factor c-Myb Primes CD4+CD8+ Immature Thymocytes for Selection Into the iNKT Lineage
Here researchers show that the transcription factor c-Myb has a central role in priming double-positive (DP) thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, the half-life of DP cells and expression of SLAMF1, SLAMF6 and SAP. [Nat Immunol]

The Zinc-Finger Protein MAZR is Part of the Transcription Factor Network that Controls the CD4 Versus CD8 Lineage Fate of Double-Positive Thymocytes
MAZR is part of the transcription factor network that regulates the CD8 lineage differentiation of double-positive thymocytes. [Nat Immunol]

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis
Here, researchers show that monocyte-derived inflammatory dendritic cells that express E-cadherin, the receptor for CD103, promote intestinal inflammation. [Immunity]

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins
These results provide an indirect mechanism of cross-inhibition of toll-like receptors and delineate a signaling pathway important for deactivation of macrophages. [ Immunity]

A Defunctioning Polymorphism in FCGR2B is Associated with Protection Against Malaria but Susceptibility to Systemic Lupus Erythematosus
Researchers show that a single-nucleotide polymorphism in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to systemic lupus erythematosus in both Caucasians and Southeast Asians. [Proc Natl Acad Sci U S A]

T and B Cell Hyperactivity and Autoimmunity Associated with Niche-Specific Defects in Apoptotic Body Clearance in TIM-4-Deficient Mice
In this study, researchers describe the generation of TIM-4-deficient mice and address whether TIM-4 serves a unique function in vivo. [Proc Natl Acad Sci U S A]

TGF-Beta Enhances Effector Th1 Cell Activation but Promotes Self-Regulation Via IL-10
Using myelin-specific T cell receptor transgenic mice, researchers demonstrate that TGF-beta elicits differential effects on naive versus effector Th1 cells. [J Immunol]

Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice
In this study, researchers investigated the molecular mechanism of PYNOD’s anti-inflammatory activity in vitro and its expression and function in mice. [J Immunol]

Activation of Murine Macrophages Via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1
Researchers demonstrate in this study that the Src family kinase Lyn negatively regulates TLR signaling in murine bone marrow-derived macrophages and in vivo. [J Immunol]

Association between Residences in U.S. Northern Latitudes and Rheumatoid Arthritis: A Spatial Analysis of the Nurses’ Health Study
The etiology of rheumatoid arthritis (RA) remains largely unknown although epidemiologic studies suggest genetic and environmental factors may play a role. Geographic variation in incident RA has been observed at the regional level. [Environ Health Perspect]


UTHealth Stem Cell Scientists Explore Treatments for Blood Disorders and Lung Diseases
Stem cell scientists at The University of Texas Health Science Center at Houston were awarded stimulus grants totaling almost $2 million to research experimental treatments for blood disorders and inherited lung diseases affecting children. [The University of Texas Health Science Center Press Release]

Baxter Drug Helps Alzheimer’s Patients Maintain Brain (Update1)
Baxter International’s treatment for immune system disorders also helped Alzheimer’s patients retain brain size and function after 18 months in a study that suggests the drug may top current regimens, researchers said. [Bloomberg]


University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues
Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States]

National Human Genome Research Institute Names New Chief of Genome Technology Branch
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States]

Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States]

Clinical Investigator Status (Biologics) [Food and Drug Administration, United States]

Background on Study Results of U.S. Academic Researchers [Food and Drug Administration, United States]

Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Department of Health & Human Services, United States]


American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

23rd Annual Canadian Society for Immunology (CSI) Conference
April 23-26, 2010
Niagara Falls, Canada

97th Annual Meeting of the American Association of Immunologists (AAI)
May 7-11, 2010
Baltimore, United States

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

Select BioSciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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