Volume 2.12 | Apr 9

Immune Regulation News 2.12, April 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Immune System Key: New Study Questions Earlier Conclusions about the Kinetics of T Cell Receptors
Based on two techniques that mechanically study receptors as they operate on T cell membranes, the findings could lead to a reevaluation of prior conclusions. [Press release from Georgia Institute of Technology discussing online prepublication in Nature]

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Researchers Use Nanoparticle “Vaccine” to Cure Type 1 Diabetes in Mice
Using an innovative nanotechnology-based “vaccine,” researchers were able to successfully restore normal blood sugar in mice with type 1 diabetes, and also slow the onset of diabetes in mice at risk for the disease. [Press release from Juvenile Diabetes Research Foundation discussing online prepublication in Immunity]

University of Central Florida Professor Harnesses Plant ‘Power’ to Fight Hemophilia
Treating hemophilia can sometimes be deadly because many patients suffer fatal allergic reactions to the expensive protein that doctors use to make their blood clot. Now researchers have devised a way that could help patients develop a tolerance to the therapeutic protein before they seek treatment to prevent the potentially deadly reactions. [Press release from University of Central Florida discussing online prepublication in Proceedings of the National Academy of Sciences U S A]



Conversion of Adult Pancreatic Alpha-Cells to Beta-Cells After Extreme Beta-Cell Loss
Researchers show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation. [Nature]

The Kinetics of Two-Dimensional TCR and pMHC Interactions Determine T Cell Responsiveness
2D data suggest rapid antigen sampling by T cells and serial engagement of a few agonist peptide-major histocompatibility complexes (pMHCs) by T cell receptor (TCR)s in a large self pMHC background. Thus, the cellular environment amplifies the intrinsic TCR-pMHC binding to generate broad affinities and rapid kinetics that determine T cell responsiveness. [Nature]

Protein Kinase C-Theta Mediates Negative Feedback on Regulatory T Cell Function
Inhibition of PKC-theta protected regulatory T cell (Treg) from inactivation by TNF-alpha, restored activity of defective Treg from rheumatoid arthritis patients, and enhanced protection of mice from inflammatory colitis. [Science]

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
Researchers suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, thereby facilitating tumor progression. [Science]

T Helper Type 1 and 17 Cells Determine Efficacy of Interferon-Beta in Multiple Sclerosis and Experimental Encephalomyelitis
Investigators have found congruence in outcome between responses to interferon-beta in experimental autoimmune encephalomyelitis and relapsing-remitting multiple sclerosis. [Nat Med]

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells
Researchers show that progression to autoimmune diabetes results in the conversion of naive low-avidity autoreactive CD8+ T cells into memory-like autoregulatory cells that can be expanded in vivo with nanoparticles coated with disease-relevant peptide-major histocompatibility complexes. [Immunity]

TRAF6 Inhibits Th17 Differentiation and TGF-Beta-Mediated Suppression of IL-2
Here researchers report that CD4+ T cells lacking the molecular adaptor TNF receptor-associated factor 6 (TRAF6) exhibit a specific increase in Th17 differentiation in vivo and in vitro. [Blood]

Toll-Like Receptor Induced Changes in Glycolytic Metabolism Regulate Dendritic Cell Activation
These data pinpoint toll-like receptor-mediated metabolic conversion as essential for dendritic cell maturation and function, and reveal it as a potential target for intervention in the control of excessive inflammation and inappropriately regulated immune responses. [Blood]

Plasmacytoid Dendritic Cells Resident in Human Thymus Drive Natural Regulatory T Cell Development
Here researchers report that plasmacytoid dendritic cells (pDCs) resident in the human thymus, when activated with CD40L plus IL-3, efficiently promoted the generation of CD4+CD25+Foxp3+ natural regulatory T cells from autologous thymocytes. [Blood]

Lentiviral-Mediated Foxp3 RNAi Suppresses Tumor Growth of Regulatory T Cell-Like Leukemia in a Murine Tumor Model
Inhibiting Foxp3 gene expression by shRNAs effectively decreases tumor growth of regulatory T cell-like leukemia. [Gene Ther]


US Seeks to Make Science Free For All
Moves to make research funded by the US government available to everyone could mark a turning point in a publishing revolution. [Nature News]

CureDM Partners Novel Diabetes Treatment With Sanofi-Aventis
CureDM, LLC announced that an agreement has been signed with Sanofi-Aventis for the exclusive worldwide license of Pancreate™, a novel islet neogenesis agent for the treatment of type 1 and type 2 diabetes. [CureDM, LLC. Press Release]

Portola Pharmaceuticals Announces Initiation of Phase I Clinical Trial of PRT062607, an Oral, Syk-Specific Inhibitor for Chronic Inflammatory Disease Indications
Portola Pharmaceuticals, Inc. announced that it has initiated its first in human Phase I trial in healthy volunteers of PRT062607, a novel, oral Syk-specific kinase inhibitor in development to treat chronic inflammatory diseases, including rheumatoid arthritis, and certain cancers, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. [Portola Pharmaceuticals, Inc. Press Release]


Enhancing Peer Review: Updated Processes for the Review of All Ruth L. Kirschstein National Research Service Award Fellowship Applications (NOT-OD-10-071) [National Institutes of Health, United States]

NIH Will Require the Electronic Submission of Appointment Forms and Termination Notices via xTrain for Research Training, Fellowship, Education, and Career Awards Beginning January 2011 (NOT-OD-10-072) [National Institutes of Health, United States]

Small Business Innovation Research Award Levels Adjusted to $150,000 (Phase I) and $1,000,000 (Phase II) (NOT-OD-10-079) [National Institutes of Health, United States]

Notice of Change in Expiration Date for Program Announcement on Bioengineering Research Partnerships (PAR-07-352) (NOT-EB-10-001) [National Institutes of Health, United States]

Revision of the Requirements for Constituent Materials (Docket No. FDA-2010-N-0099) [Food and Drug Administration, United States]

Voting and Nonvoting Consumer Representative Members on Public Advisory Committees and Panels; Notice of Public Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Determination of Regulatory Review Period for Purposes of Patent Extension; LUSEDRA (Docket Nos. FDA-2009-E-0202 and FDA-2009-E-0204) [Food and Drug Administration, United States]

Revision of Organization and Conforming Changes to Regulations (Docket No. FDA-2010-N-0148) [Food and Drug Administration, United States]

Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment (Docket No. FDA-1999-N-3539) [Food and Drug Administration, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Food and Drug Administration, United States]


American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

23rd Annual Canadian Society for Immunology (CSI) Conference
April 23-26, 2010
Niagara Falls, Canada

97th Annual Meeting of the American Association of Immunologists (AAI)
May 7-11, 2010
Baltimore, United States

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

7th Annual RNAi & miRNA Europe Select BioSciences
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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