Volume 2.10 | Mar 19

Immune Regulation News 2.10, March 19, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Medical Research Council Scientists Announce Advance in Understanding Body’s Natural Defences
Researchers showed that a newly discovered protein, HVCN1, regulates antibody production through modulation of intracellular oxidation. In the absence of HVCN1, the immune response is blunted. [Press release from University of Leicester discussing online prepublication in Nature Immunology]

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Double Agents: Penn Researchers Identify Immune Cells That Fight Parasites May Promote Allergies and Asthma
Researchers, studying how the immune system operates, have discovered a previously unidentified cell population that may be the body’s double-edged sword, fighting off parasitic infections but also causing the harmful immune responses that can lead to allergies and asthma. [University of Pennsylvania Press Release]

How Cells Protect Themselves from Cancer
Now for the first time, using an animal model for lymphoma, cancer researchers have shown that two protection programs work together through an interaction with normal immune cells to prevent tumors. [Press release from ScienceDaily discussing online prepublication in Cancer Cell]



CD169+ Macrophages Present Lipid Antigens to Mediate Early Activation of i NKT Cells in Lymph Nodes
Although it is known that invariant natural killer T (iNKT) cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear. [Nat Immunol]

Tumor Stroma-Derived TGF-Beta Limits Myc-Driven Lymphomagenesis Via Suv39h1-Dependent Senescence
Using the E(mu)-myc transgenic mouse lymphoma model, researchers show in vivo that apoptotic lymphoma cells activate macrophages to secrete transforming growth factor-beta as a critical non-cell-autonomous inducer of cellular senescence. [Cancer Cell]

Complement Receptor 2/CD21-Negative Human Naive B Cells Mostly Contain Autoreactive Unresponsive Clones
Researchers found that some rheumatoid arthritis patients display an increased frequency of CD21-/lo B cells in their blood. [Blood]

Genomic Definition of Multiple Ex Vivo Regulatory T Cell Subphenotypes
For a better perspective on transcriptional control in regulatory T (Treg) cells, researchers compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. [Proc Natl Acad Sci USA]

Notch Signaling Drives IL-22 Secretion in CD4+ T Cells by Stimulating the Aryl Hydrocarbon Receptor
This study identifies a Notch-aryl hydrocarbon receptor axis that regulates IL-22 expression and fine-tunes immune system control of inflammatory responses. [Proc Natl Acad Sci USA]

Dendritic Cells Control T Cell Tonic Signaling Required for Responsiveness to Foreign Antigen
These findings indicate that dendritic cells are specialized cells that not only present foreign antigen, but also promote a “tonic” state in T cells for antigen responsiveness. [Proc Natl Acad Sci USA]

Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients
These results provide evidence that chemokine receptor type 4 (CCR4) might play a role in allergen-driven Th2 cell accumulation in asthmatic airways. Targeting this chemokine receptor in patients with asthma might reduce Th2 cell-driven airway inflammation; therefore, CCR4 antagonists could be an effective new therapy for asthma. [J Immunol]

Polycomb Group Gene Product Ring1B Regulates Th2-Driven Airway Inflammation through the Inhibition of Bim-Mediated Apoptosis of Effector Th2 Cells in the Lung
In this paper, researchers extended the study of polycomb group (PcG) molecules to the regulation of in vivo Th2 responses, especially allergic airway inflammation, by using conditional Ring1B-deficient mice with a CD4 T cell-specific deletion of the Ring1B gene (Ring1B-/- mice). [J Immunol]


Red Tape Holding Up Stem Cell Work?
Stem cell researchers are worried that they’ll have to stop work with some of their favorite cell lines. [ScienceInsider]

Epeius Biotechnologies Receives Notice Of Patent Allowance For Tumor-Targeted Cancer Vaccines
Epeius Biotechnologies Corporation received a notice of allowance from the United States Patent and Trademark Office for a crucial patent covering its leading tumor-targeted vaccine technology for cancer immunotherapy. [Biocompare]

Viron Reports Positive Proof of Concept Results in Arthritis for its VT-346 Anti-TNF Therapeutic
Viron Therapeutics Inc. announced that VT-346, an anti-TNF protein therapeutic, demonstrated positive results in a pivotal proof of concept study in the gold standard transgenic mouse model for arthritis. [Viron Therapeutics Inc., Press Release]

Cellzome Announces Second Major Strategic Drug Discovery Alliance With GlaxoSmithKline In Inflammatory Disease
Cellzome announced that it has formed a second strategic alliance with GlaxoSmithKline (GSK). This new collaboration gives GSK exclusive access to Cellzome’s proprietary Episphere™ technology in the emerging field of epigenetics as applied to immunoinflammatory disease. [Cellzome Press Release]


California Institute for Regenerative Medicine Allocates $50 Million for Stem Cell Therapy Development, a Boost for the State’s Growing Stem Cell Industry
In a move that will speed the path of bringing stem cell-based therapies to the people of California, the Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by Proposition 71, approved a concept proposal for funding the development of new stem cell therapies. [California Institute for Regenerative Medicine, United States]

Spain Turns to Science for Stimulus
Spain’s ministers recently approved the text of a new research law that aims to reward scientific talent and encourage entrepreneurship. [Science and Innovation Ministry, Spain]

Technical Assistance for RFA-RM-10-006: Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01) (NOT-RM-10-003) [National Institutes of Health, United States]

Modification: This Notice Modifies RFA-RM-09-019 (NOT-RM-10-004)
[National Institutes of Health, United States]

Notice of a Change in the Next Receipt Date for the Center of Biomedical Research Excellence Program Announcement (PAR-09-079) (NOT-RR-10-005) [National Institutes of Health, United States]

Notice of Intent to Publish a Funding Opportunity for the Reissue of RFA-TW-08-002 the International Research Ethics Education and Curriculum Development Award (R25) (NOT-TW-10-326)
[National Institutes of Health, United States]

Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01) (PA-10-125) [National Institutes of Health, United States]


World Immune Regulation Meeting (WIRM) – IV
March 29-April 01, 2010
Davos, Switzerland

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

23rd Annual Canadian Society for Immunology (CSI) Conference
April 23-26, 2010
Niagara Falls, Canada

97th Annual Meeting of the American Association of Immunologists (AAI)
May 7-11, 2010
Baltimore, United States

29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom

Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland

Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

4th Asian Congress on Autoimmunity
September 11-13, 2010
Singapore City, Singapore

7th Annual RNAi & miRNA Europe Select BioSciences
September 14-15, 2010
Dublin, Ireland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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