Volume 2.09 | Mar 12

Immune Regulation News 2.09, March 12, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

University of Michigan Scientists Identify Reservoirs Where HIV-Infected Cells Can Lie in Wait
Scientists have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections. [Press release from University of Michigan discussing online prepublication in Nature Medicine]

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SCIENCE NEWS

Alzheimer’s-Associated Protein May Be Part Of The Innate Immune System
Amyloid-beta protein – the primary constituent of the plaques found in the brains of Alzheimer’s disease patients – may be part of the body’s first-line system to defend against infection. [Press release from Massachusetts General Hospital discussing online prepublication in PLoS One]

Immune Cells Use Bungee of Death to Kill Dangerous Cells, Shows New Research
The study shows that natural killer cells use a bungee-like nanotube to destroy cells that could otherwise escape them. [Press release from Imperial College London discussing online prepublication in Proceedings of the National Academy of Sciences]

New Approach to Immune Cell Analysis Seen as First Step to Better Distinguish Health and Disease
Investigators have developed a new mathematical approach to analyze molecular data derived from complex mixtures of immune cells. [National Institutes of Health News Press Release]

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CURRENT PUBLICATIONS

HIV-1 Infects Multipotent Progenitor Cells Causing Cell Death and Establishing Latent Cellular Reservoirs
Here researchers used CD34+ cells from infected people as well as in vitro studies of wild-type HIV to show infection and killing of CD34+ multipotent hematopoietic progenitor cells. [Nat Med]

Vitamin D Controls T Cell Antigen Receptor Signaling and Activation of Human T Cells
Researchers show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor responsiveness in naive T cells. [Nat Immunol]

Regulation of Leukocyte Recruitment by the Long Pentraxin PTX3
PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown in this study, glycosylation-dependent regulation of inflammation. [ Nat Immunol]

Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help
To simulate transient B cell activation that is the likely initiator of T-dependent responses, researchers examined the molecular and functional consequences of a single round of immunoglobulin M (IgM) signaling. [Immunity]

CD81 Gene Defect in Humans Disrupts CD19 Complex Formation and Leads to Antibody Deficiency
In this study, researchers present what they believe to be the first antibody deficiency syndrome caused by a mutation in the CD81 gene and consequent disruption of the CD19 complex on B cells. [J Clin Invest]

Membrane Nanotubes Facilitate Long-Distance Interactions between Natural Killer Cells and Target Cells
Nanotubes allow human natural killer cells to interact functionally with target cells over long distances. [Proc Natl Acad Sci USA]

Toxin-Coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice
Researchers show that saporin-coupled tetramers can delete islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive T cells in vitro and in vivo. [J Immunol]

Uncoordinated 119 Preferentially Induces Th2 Differentiation and Promotes the Development of Asthma
Using adoptive transfer of signalling protein uncoordinated 119 (Unc119)-knockdown CD4 T cells, researchers show a critical role for Unc119 in the development of eosinophilic inflammation of airways, mucus production, and bronchial hyperreactivity in a mouse model. [J Immunol]

T Cell Ig Domain and Mucin Domain 1 Engagement on Invariant NKT Cells in the Presence of TCR Stimulation Enhances IL-4 Production but Inhibits IFN-Gamma Production
The results suggest that T cell Ig domain and mucin domain1 (TIM1) costimulation on natural killer T (NKT) cells enhances the cellular production of IL-4 while inhibiting the production of IFN-gamma. [J Immunol]

INDUSTRY NEWS

Canadian Budget Light on New Research Dollars
Relief was the order of the day for Canadian scientists recently as the federal government brought down its fiscal blueprint for 2010-11. [ScienceInsider]

In Annual Rite, Chinese Science Showered with Riches
At the opening session of the National People’s Congress, officials announced that the science and technology budget will rise 8% to 163.3 billion RMB ($24 billion) in 2010. [ScienceInsider]

USPTO Grants Advaxis New Listeria Based Fusion Protein Patent
The US Patent and Trademark Office (USPTO) has issued Advaxis, Inc. patent #7662396 titled “Compositions and Methods for Enhancing the Immunogenicity of Antigens” for the use of fusion proteins that have been found to be effective in numerous models for the treatment of cancer in the presence of immune tolerance. [Yahoo! Finance]

Mologen AG Receives Approval for Clinical Study with Cancer Drug MGN1703
The Berlin biotech company Mologen has received approval from the competent German and Austrian health authorities at the Paul Ehrlich Institute and the Federal Office for Safety in Health Care, respectively, to conduct a phase II study on the cancer drug MGN1703. [Mologen AG Press Release]

POLICY NEWS

Request for Information (RFI): To Solicit Input for the National Institute of General Medical Sciences (NIGMS) Strategic Plan for Training and Career Development (NOT-GM-10-102) [National Institutes of Health, United States]

Correction to Required Budget Component for PAR-09-084: Enhancing Developmental Biology Research at Undergraduate Institutions Academic Research Enhancement Award (R15) (NOT-HD-10-007) [National Institutes of Health, United States]

Clarification of Budget Form for PAR-09-092 Academic-Community Partnership Conference Series (U13) (NOT-HD-10-009) [National Institutes of Health, United States]

Recovery Act Limited Competition: The NIH Director’s American Recovery & Reinvestment Act Funded Pathfinder Award to Promote Diversity in the Scientific Workforce (DP4) (RFA-OD-10-013) [National Institutes of Health, United States]

Minority Access to Research Careers Undergraduate Student Training in Academic Research (U-STAR) National Research Service Award (NRSA) Institutional Research Training Grant (T34) (PAR-10-119) [National Institutes of Health, United States]

Strategic Partnering to Evaluate Cancer Signatures [SPECS II] (U01) (PAR-10-126) [National Cancer Institute, United States]

Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01) (PA-10-125) [National Institute of General Medical Sciences, United States]

DIA/FDA CDER/CBER Computational Science Annual Meeting, Posted [Food and Drug Administration, United States]

Guidance for Industry: Characterization and Qualification of Cell Substrates and Other Biological Materials Used in the Production of Viral Vaccines for Infectious Disease Indications; Availability [Food and Drug Administration, United States]

EVENTS

World Immune Regulation Meeting (WIRM) – IV
March 29-April 01, 2010
Davos, Switzerland


American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States


23rd Annual Canadian Society for Immunology (CSI) Conference
April 23-26, 2010
Niagara Falls, Canada


97th Annual Meeting of the American Association of Immunologists (AAI)
May 7-11, 2010
Baltimore, United States


29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
June 5-9, 2010
London, United Kingdom


Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
June 7-12, 2010
Dublin, Ireland


Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States

Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan


Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

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