Volume 2.02 | Jan 22

Immune Regulation News 2.02, January 22, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Cancer Stem Cells Suppress Immune Response Against Brain Tumor
Cancer-initiating cells that launch glioblastoma multiforme, the most lethal type of brain tumor, also suppress an immune system attack on the disease. [M. D. Anderson Cancer Center, Houston]

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SCIENCE NEWS

How Anticancer Immune Responses Are Suppressed
Scientists have identified a molecular pathway that enhances the immunosuppressive functions of tumor-associated mouse and human myeloid-derived suppressor cells. [Science Daily]

Identified: Switch that Turns On Allergic Disease in People
A new study in human cells has singled out a molecule that specifically directs immune cells to develop the capability to produce an allergic response. The signaling molecule, called thymic stromal lymphopoietin, is key to the development of allergic diseases such as asthma, atopic dermatitis (eczema) and food allergy. [M. D. Anderson Cancer Center, Houston]

Babraham Discovery May Aid Transplantation and Regenerative Medicine
Research provides new insights into how our immune system produces T cells, a type of white blood cell that is an essential part of the body’s immune surveillance system for fighting infection. [Babraham Institute, Cambridge]

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CURRENT PUBLICATIONS

Effectors and Memories: Bcl-6 and Blimp-1 in T and B Lymphocyte Differentiation
The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. [Nat Immunol]

Membrane-Associated Hsp72 from Tumor-Derived Exosomes Mediates STAT3-Dependent Immunosuppressive Function of Mouse and Human Myeloid-Derived Suppressor Cells
Here, researchers have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and myeloid-derived suppressor cells (MDSCs) determines the suppressive activity of the MDSCs via activation of Stat3. [J Clin Invest]

The Architectural Pattern of FOXP3-Positive T Cells in Follicular Lymphoma is an Independent Predictor of Survival and Histologic Transformation
Researchers conclude that FOXP3+ cell distribution significantly predicts survival and risk of transformation in follicular lymphoma. [Blood]

Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4+ T Cells
In this study, researchers generated human monocyte-derived dendritic cells (DCs) by culture with GM-CSF and IL-4 (control DCs), as well as tolerogenic DCs (tDCs) by adding IL-10, IL-10/TGF-(beta)1, or IL-10/IL-6. [J Immunol]

Myelin Basic Protein Priming Reduces the Expression of FOXP3 in T Cells Via Nitric Oxide
The present study was undertaken to investigate the crosstalk between nitric oxide and regulatory T cells. [J Immunol]

Dendritic Cells Support Homeostatic Expansion of FOXP3+ Regulatory T Cells in Foxp3.LuciDTR Mice
For the investigation of regulatory T cell (Treg) homeostatic expansion, researchers introduced in this study novel BAC transgenic mice, designated Foxp3.LuciDTR, coexpressing enhanced GFP, luciferase for bioluminescence imaging of Tregs, and the diphtheria toxin receptor for specific ablation of Tregs. [J Immunol]

Ex Vivo Monitoring of Human Cytomegalovirus-Specific CD8+ T Cell Responses Using the QuantiFERON(R)-CMV Assay in Allogeneic Hematopoietic Stem Cell Transplant Recipients Attending an Irish Hospital
The QuantiFERON®-CMV assay for cellular human cytomegalovirus-specific immunity was evaluated in allogeneic hematopoietic stem cell transplant recipients recipients (n = 43) and patients with hematological malignancies (n = 29) attending a tertiary-care Irish hospital.  [J Med Virol]

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INDUSTRY NEWS

Novartis Edges Ahead of Merck KGaA in Multiple Sclerosis Race
Swiss drugmaker Novartis has edged ahead of German rival Merck KGaA in the race to get the first oral multiple sclerosis treatment to market, having now filed for approval in the United States and Europe. [Reuters Press Release]

Fast Forward, Juvenile Diabetes Research Foundation And Axxam SpA Join Forces To Develop Treatments For Multiple Sclerosis And Type 1 Diabetes
Fast Forward, LLC, and the Juvenile Diabetes Research Foundation announced a collaborative partnership with Axxam SpA to develop new treatments for two autoimmune diseases, multiple sclerosis and type 1 diabetes. [Axxam SpA Press Release]



POLICY NEWS

Advisory Committees; Tentative Schedule of Meetings for 2010 [Food and Drug Administration, United States]

Proposed FDA Rulemaking on Informed Consent Requirements (NOT-OD-10-046) [National Institutes of Health, United States]

PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (PA-10-051) [National Institutes of Health, United States]

IACUC 101 and 201 PLUS Workshops: February 24-25, 2010 in Lafayette, LA (NOT-OD-10-044) [National Institutes of Health, United States]

EVENTS

9th International Conference on New Trends in Immunosuppression and Immunotherapy
February 4-6, 2010
Geneva, Switzerland

13th International Conference on Lymphocyte Activation and Immune Regulation: Inflammasome and Inflammation
February 5-7, 2010
Newport Beach, United States

Keystone Symposia: Tolerance and Autoimmunity
February 21-26, 2010
Taos, United States

World Immune Regulation Meeting – IV
March 29-April 1, 2010
Davos, Switzerland

IMMUNOLOGY 2010
May 7-11, 2010
Baltimore, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

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