Volume 12.22 | Jun 19

2020-06-19 | Jun 19
Immune Regulation News by STEMCELL Technologies
Vol. 12.22 – 19 June, 2020
TOP STORY

Senolytic CAR T Cells Reverse Senescence-Associated Pathologies

Investigators tested the therapeutic concept that chimeric antigen receptor (CAR) T cells that target senescent cells could be effective senolytic agents. They identified the urokinase-type plasminogen activator receptor (uPAR)11 as a cell-surface protein that is broadly induced during senescence and showed that uPAR-specific CAR T cells efficiently ablated senescent cells in vitro and in vivo.
[Nature]

AbstractPress Release

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PUBLICATIONSRanked by the impact factor of the journal

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis

The authors suggested that urea cycle hyperreactivity and excessive polyamine generation in psoriatic keratinocytes promoted self-RNA sensation and highlighted protein phosphatase 6 deregulation in keratinocytes as a pivotal event that amplified the inflammatory circuits in psoriasis.
[Immunity]

AbstractGraphical Abstract

Eosinophil Function in Adipose Tissue Is Regulated by Krüppel-Like Factor 3 (KLF3)

Researchers examined the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging.
[Nature Communications]

Full Article

Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis

Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Nonexposed Mucosal Organs and Primes for Allergic Inflammation

Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
[Mucosal Immunology]

Abstract

Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells

Scientists explored how using a synthetic cell-penetrating peptide mimic for intracellular anti-protein kinase C theta delivery fine-tuned differentiation of induced regulatory T cells, through its differential effects on RNA processing.
[Molecular Therapy]

AbstractGraphical Abstract

Vagus Nerve Stimulation Even after Injury Ameliorates Cisplatin-Induced Nephropathy via Reducing Macrophage Infiltration

To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports]

Full Article

Apatinib Prevents Natural Killer Cell Dysfunction to Enhance the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma

Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy]

Abstract

Intratumoral Immune Activation with TLR4 Agonist Synergizes with Effector T Cells to Eradicate Established Murine Tumors

Scientists combined intratumoral administration of the synthetic toll-like receptor 4 agonist glucopyranosyl lipid A with either active vaccination or adoptive transfer of tumor-specific CD8 T cells to mice bearing established melanomas.
[Npj Vaccines]

Full Article

The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

Researchers assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]

Abstract

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REVIEWS

Determinants of Resident Tissue Macrophage Identity and Function

The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
[Immunity]

Abstract

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Investigators explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]

Abstract

Tumor-Induced Neurogenesis and Immune Evasion as Targets of Innovative Anti-Cancer Therapies

Scientists discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy]

Full Article

INDUSTRY AND POLICY NEWS

US Science Groups Wary of New Senate Bills to Curb Foreign Influences

A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider]

Editorial

Principia Presents Updated Positive Data of Rilzabrutinib for Immune Thrombocytopenia in Ongoing Phase I/II Trial

Principia Biopharma, Inc. announced positive data on durability of response from an ongoing Phase I/II trial of its investigational treatment, rilzabrutinib.
[Principia Biopharma, Inc.]

Press Release

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2020-07-16 – 2020-07-17
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JOB OPPORTUNITIES

Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

Lund University – Lund, Sweden

Research Associate – Cancer Immunology

King’s College London – London, United Kingdom

Professor – Immunology

Lund University – Scania, Sweden

Postdoctoral Researcher – Genetic Engineering of Dendritic Cells

Aarhus University – Aarhus C, Denmark

Postdoctoral Associate – G Protein-Coupled Receptors

Howard Hughes Medical Institute – Durham, North Carolina, United States

Postdoctoral Fellow – Mechanisms of Autoimmune Disease

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

PhD Studentship – Antibody Diversity

University of Southern Denmark – Odense M, Denmark

Postdoctoral Fellowships – Autoimmune Conditions

Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States

Postdoctoral Associate – Immunology and Mitochondrial Biology

Texas A&M Health Science Center – College Station, Texas, United States

Principle Scientist – Immunology and Gene Engineering

Empyrean Therapeutics Ltd – Cambridge, United Kingdom

Principle Scientist – Cancer and Auto-Immune Disorders

Sanofi – La Jolla, California, United States

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